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New Technology for Measurement of Cell Potential
Present methods of measuring intracellular potentials involve processes that breach
the cell membrane. The breaching of the cell membrane causes errors due to fluid
exchange effects and ultimately destroys the cell. In addition, current techniques
either require highly skilled technicians or expensive consumable items, limiting
their usefulness in terms of both time and cost effectiveness.
Electronic Bio Sciences is developing a revolutionary technology based on measuring
intracellular potentials noninvasively via a capacitively coupled electrode external
to the cell. This innovation means that potentials can be monitored in undisturbed
living cells, greatly increasing the amount and quality of information that can be
obtained. In addition, the noninvasive aspect of the technology means that automated
systems could theoretically measure large numbers of cells, increasing the efficiency
of the process and enabling high-throughput screening.
Direct Measurement of Ion Channel and Protein Pore Activity
EBS has formed an international collaboration with top researchers in the fields of biology,
biochemistry, electrochemistry, ion channels and membranes, signal processing, microfluidics,
and microfabrication in order to develop a robust device capable of measuring the stochastic
current signal of a single ion channel or protein pore in real time. A compact array of such
pores will provide a biofingerprint of target analytes with a very low false alarm rate.
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